Grease Pencil branch merged into Blender 3D officially, back on July. It was the best news the 3D world was expecting since most of the 2D packages (ToonBoom, TVpaint, Kakani, OpenToonz, and others) have tried to implement 3D to some degree of success into their 2D environments.
Blender 3D on the other hand, has successfully given the users the ability to apply 3d modifiers onto 2D objects, 3D bone rigging system to 2D drawings and extending the canvas to an unlimited space and layering system through collections. Given the realtime engine Blender has (called EEVEE) you don´t need to wait for render time like all other commercial 2D software application counterparts, since EEVEE is a realtime engine! Plain English: what you see is what you get straight from the viewport.
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